The Journal of the American Medical Association contains an article titled “Chronic Fluorine Intoxication”, which states,
“fluorides are general protoplasmic poisons, changing the permeability of the cell membrane by inhibiting certain enzymes. The exact mechanisms of such actions, it was said, are obscure. The sources of fluorine intoxication are drinking water containing 1ppm or more of fluorine, fluorine compounds used as insecticidal sprays for fruits and vegetables (cryolite and barium fluorosilicate) and the mining and conversion of phosphate rock to superphosphate, which is used as a fertilizer. That process alone releases approximately 25,000 tons of pure fluorine into the atmosphere annually. Other sources of fluorine intoxication is from the fluorides used in the smelting of many metals, such as steel and aluminum, and in the production of glass, enamel and brick.”